Research progress of familial hereditary prostate cancer

VernacularTitle:家族遗传性前列腺癌的研究进展
Author: Xianchao SUN ¹ ; Weiguo MA ; Xiang LIU ; Lin YE
Author Information

1. 上海市东方医院　同济大学附属东方医院泌尿外科，上海　200120
Keywords: Prostatic neoplasms; Carcinoma; Familial and hereditary; Research progress
From: Chinese Journal of Urology 2023;44(1):68-71
CountryChina
Language:Chinese
Abstract: Hereditary prostate cancer has the highest hereditary rate in men cancers. Genes associated with hereditary prostate cancer susceptibility include mismatch repair genes (MLH1, MSH2, MSH6 and PMS2) and homologous recombination genes (BRCA1/2, ATM, PALB2, CHEK2), and single nucleotide polymorphisms and copy number variants also play a role in genetic mutations. Early onset, rapid disease progression and locally advanced stage are the main features of hereditary prostate cancer. Patients with potentially hereditary prostate cancer would benefit from undergoing genetic testing or counseling. This article reviews the current status of the prevalence, incidence characteristics, and etiology of familial hereditary prostate cancer and other research advances.