Lower urinary tract symptoms in Parkinson's disease and multiple system atrophy
10.3760/cma.j.issn.0254-9026.2023.07.022
- VernacularTitle:帕金森病和多系统萎缩的下尿路症状特点
- Author:
Mengting YANG
1
;
Zhipeng ZHANG
;
Dongdong WU
;
Wen SU
;
Haibo CHEN
Author Information
1. 北京医院神经内科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100005
- Keywords:
Parkinson's disease;
Multiple system atrophy;
Lower urinary tract symptoms;
Urodynamic examination;
Treatment
- From:
Chinese Journal of Geriatrics
2023;42(7):867-871
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)and multiple system atrophy(MSA)are two common Parkinsonian syndromes with overlapping clinical manifestations, and clinical differential diagnosis is difficult.Lower urinary tract symptoms are one of the common non-motor symptoms of the two diseases.The incidence of lower urinary tract symptoms in MSA is higher, the onset is earlier, and the micturition period is more prominent.The urinary dysfunction in patients with PD is mainly caused by the central mechanism, leading to overactive bladder.MSA has more extensive lesions with both central and peripheral involvement, leading to overactive bladder and severe voiding dysfunction.Urodynamics can be used to evaluate bladder and urethral function.MSA has more prominent weak detrusor activity, residual urine volume, and early changes of urethral sphincter.The treatment of lower urinary tract symptoms in patients with PD is mainly based on anticholinergic drugs to improve overactive bladder, while in MSA patients with increased residual urine volume, intermittent catheterization is the main method to improve lower urinary tract symptoms.This article reviewed the epidemiology, pathological mechanism, urodynamics and treatment of lower urinary tract symptoms of the two diseases, so as to assist in their differential diagnosis and treatment.
