Pathologic Change and Prognosis after Combination Therapy in Advanced Neuroblastoma.
- Author:
Yeon Kyong SEO
1
;
Yu Jin JUNG
;
Joon Sik KIM
;
Heung Sik KIM
;
Woo Hyun PARK
;
Soon Ok CHOI
;
Byung Yook LEE
;
Kun Young KWON
Author Information
1. Department of Pediatrics, School of Medicine, Keimyung University, Daegu, Korea. kimhs@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Neuroblastoma;
Pathologic change;
Prognosis
- MeSH:
Classification;
Drug Therapy;
Follow-Up Studies;
Ganglioneuroma;
Humans;
Neuroblastoma*;
Pancreatitis;
Prognosis*;
Retrospective Studies;
Sepsis;
Survival Rate
- From:Journal of the Korean Pediatric Society
2003;46(11):1107-1111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can matured from a malignant neuroblastoma into a benign ganglioneuroma. It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic features after combination therapy in advanced neuroblastoma. Prognostic effects of the individual morphologic feature and prognostic groupings according to modified Shimada classification systems were analyzed. METHODS: The treatment results for six patients with neuroblastoma seen at Keimyung University from Jan. 1991 to June 2000 were analyzed. Patients were treated with a combination of chemotherapy, radiation therapy, and surgery, and classified by two major prognostic criteria based on morphological features of neuroblastoma, such as modified Shimada classification and histologic grading. RESULTS: Three cases were classified to a good histologic group; among them, two cases survived, but one case was lost in follow-up. There were three cases classified in a poor histologic group. All of these patients expired due to sepsis and hemorrhagic pancreatitis. CONCLUSION: Prognostic classification due to pathologic findings had significant value in evaluating the survival rate of neuroblastoma patients.
