Association of AluYb8 insertion in the MUTYH gene with the risk of decreased left ventricular diastolic function in elderly diabetic patients
10.3760/cma.j.issn.0254-9026.2023.03.011
- VernacularTitle:MUTYH基因AluYb8插入变异与老年糖尿病患者左心室舒张功能减退的相关性分析
- Author:
Huixian SUN
1
;
Jie MENG
;
Yushuang LIN
;
Can ZHAO
;
Jiali LIU
;
Huiwei HE
;
Xiang LU
;
Wei GAO
Author Information
1. 南京医科大学附属逸夫医院老年医学科，南京 211166
- Keywords:
Ventricular dysfunction, left;
Diabetes mellitus;
Genetic predisposition to disease
- From:
Chinese Journal of Geriatrics
2023;42(3):297-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between AluYb8 insertion in the MUTYH gene and the risk of decreased left ventricular diastolic function in the elderly.Methods:In the retrospective analysis, 498 elderly patients with decreased left ventricular diastolic function(the disease group)and 155 people without left ventricular diastolic function(the control group)were recruited.Polymerase chain reaction was employed to analyze the genotype distribution of AluYb8 insertion in MUTYH gene.Cardiac function was measured by high-resolution color Doppler ultrasound.Results:The frequencies of the A/A, A/P and P/P genotypes were 30.1%(150/498), 48.4%(241/498)and 21.5%(107/498)in patients with decreased left ventricular diastolic function, and 27.7%(43/155), 54.8%(85/155)and 17.5%(27/155)in the control group, respectively.There were no significant differences in genotype( χ2=2.162, P=0.339)and allele frequency( χ2=1.342, P=0.794)between the two groups.Further analysis after stratification revealed that there were statistically significant differences in genotype( χ2=7.173, P=0.028)and allele frequency( χ2=8.352, P=0.015). Multivariate Logistic regression analysis showed that, in elderly patients with diabetes, P-allele carriers had a higher risk of decreased left ventricular diastolic function than non-carriers( OR=3.450, 95% CI: 1.148-10.372, P=0.027). Conclusions:AluYb8 insertion in the MUTYH gene may be associated with the risk of decreased left ventricular diastolic function in the elderly with diabetes.
