A Case of Acute Pancreatitis in a Neuroblastoma Patient after Retinoic Acid Therapy.
- Author:
Yoo Jin JEONG
1
;
Yeon Kyong SEO
;
Heung Sik KIM
;
Hee Jung LEE
Author Information
1. Department of Pediatrics, School of Medicine, Keimyung University, Taegu, Korea. kimhs@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Retinoic acid;
Acute pancreatitis;
Hyperlipidemia;
Neuroblastoma
- MeSH:
Headache;
Hemorrhage;
Humans;
Hyperlipidemias;
Leukemia, Promyelocytic, Acute;
Mouth;
Neuroblastoma*;
Pancreatitis*;
Parenteral Nutrition, Total;
Skin;
Tretinoin*
- From:Journal of the Korean Pediatric Society
2003;46(11):1128-1130
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Retinoic acid has been used successfully as a differentiating agent in acute promyelocytic leukemia and neuroblastoma. However, some adverse effects have been recognized, such as headaches, dry skin and retinoic acid syndrome, a life threatening acute cardiorespiratory disorder. Acute pancreatitis with hyperlipidemia has rarely been reported. We experienced a case of acute pancreatitis with hyperlipidemia in a neuroblastoma patient after retinoic acid therapy for 21 months. Although the patient was ordered nothing by mouth and total parenteral nutrition was administrated, she died of disseminated intravascular coagulopathy and pulmonary hemorrhage, possibly because of oral intake during her recovery period.
