Aplastic Crisis Secondary to Parvovirus B19 Infection.
- Author:
Yang Joon PARK
1
;
Dae Kyun KOH
;
Jin Hee OH
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. kdk7016@hanmail.net
- Publication Type:Case Report
- Keywords:
Aplastic Crisis;
Parvovirus B19;
Hereditary spherocytosis
- MeSH:
Anemia, Hemolytic;
Bone Marrow;
Bone Marrow Examination;
Cell Lineage;
Child;
Erythema Infectiosum;
Erythroid Precursor Cells;
Erythropoiesis;
Hematopoiesis;
Humans;
Immunocompromised Host;
Immunoglobulin M;
Immunoglobulins;
Pancytopenia;
Parvovirus*
- From:Journal of the Korean Pediatric Society
2003;46(11):1139-1142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with hereditary spherocytosis who developed transient aplastic crisis. A HPV B19 infection was confirmed by IgM anti-B19 parvovirus titers and characteristic findings of bone marrow examination as the causative agent associated with severe pancytopenia. Three patients recovered spontaneously after a short period of supportive care with red cell transfusions and intravenous immunoglobulin.
