Clonal hematopoiesis of indeterminate potential and aging

VernacularTitle:不确定潜能的克隆性造血与衰老
Author: Hongtao LAN ¹ ; Zhoujie TONG ; Ying MA ; Zhihao WANG
Author Information

1. 山东大学齐鲁医院老年医学科　山东省心血管蛋白质组学重点实验室，济南　250012
Keywords: Hematologic neoplasms; Aging; Clonal hematopoiesis of indeterminate potential; Epigenetic modification
From: Chinese Journal of Geriatrics 2022;41(12):1530-1534
CountryChina
Language:Chinese
Abstract: Clonal hematopoiesis with indeterminant potential(CHIP)is defined as the proportion of detectable clonal hematopoietic cells in peripheral blood exceeding 2% and without confirmed hematologic malignancy.CHIP could increase the risk of malignant diseases through changes in DNA damage response, transcriptional programming and epigenetic modification.The incidence of malignant tumors in the blood system is significantly higher in the CHIP patients than healthy person.In addition, CHIP represents a negative factor associated with aging.Recent studies have found that the incidences of infections, anemia, heart failure, thrombotic events, and tumors of the blood system in CHIP carriers were significantly increased.Starting with the epigenetic modifications, phenotypic changes and inflammatory mechanisms of CHIP-related gene mutations, this paper discussed the mechanisms of CHIP-related diseases and possible intervention aimed at aging.