Advances on myeloid-derived suppressor cells in hepatitis B virus infection
10.3760/cma.j.issn.1674-2397.2023.03.013
- VernacularTitle:髓源性抑制细胞在乙型肝炎病毒感染中的研究进展
- Author:
Shifen WANG
1
;
Ni YAO
;
Yan LYU
;
Yuhong ZHAO
;
Dawei CUI
;
Jue XIE
Author Information
1. 浙江大学医学院附属第一医院输血科，杭州 310003
- Keywords:
Myeloid-derived suppressor cells;
Hepatitis B virus;
Chronic hepatitis B;
End-stage liver disease
- From:
Chinese Journal of Clinical Infectious Diseases
2023;16(3):234-240
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous cells that can inhibit T cell function. In pathological conditions such as tumors, infections, and chronic inflammation, the large expansion of MDSCs is involved in processes of immune escape, immune tolerance and inflammatory reactions. MDSCs are also crucial in the pathophysiology of hepatitis B virus (HBV) infection, however, their activation, differentiation, and function during HBV infection are still unclear. This article reviews the general characteristics and roles of MDSCs in HBV infection, as well as related drug therapies, in order to provide information for further research on the related mechanism and potential targeted treatment.
