Efficacy of vitamin D adjuvant therapy for prevention of spontaneous bacterial peritonitis in patients with decompensated cirrhosis of hepatitis B
10.3760/cma.j.issn.1674-2397.2023.03.009
- VernacularTitle:维生素D辅助治疗对预防乙型肝炎失代偿期肝硬化患者发生自发性细菌性腹膜炎的临床效果分析
- Author:
Yang ZHANG
1
;
Haijun CHEN
;
Yejin XU
;
Dehe ZHANG
;
Jing ZHOU
;
Shengnan LUO
Author Information
1. 浙江大学医学院附属金华医院感染病科 321000
- Keywords:
Hepatitis B;
Decompensated liver cirrhosis;
Spontaneous bacterial peritonitis;
Vitamin D
- From:
Chinese Journal of Clinical Infectious Diseases
2023;16(3):215-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of vitamin D supplementation for prevention of spontaneous bacterial peritonitis (SBP) in patients with decompensated liver cirrhosis of hepatitis B.Methods:A total of 172 patients with decompensated cirrhosis of hepatitis B admitted in Jinhua Hospital affiliated to Zhejiang University School of Medicine from January to December 2021 were randomly divided into two groups with 86 cases in each group. Patients in both groups received conventional antiviral and symptomatic treatment; while patients in the intervention group received additinal oral vitamin D drops (800 IU/d) for 6 months. After 6 months of treatment, the incidence of SBP and the serum biochemical indexes were compared between two groups. SPSS 21.0 statistical software was used for data analysis.Results:After 6 months of treatment, the incidence of SBP in the intervention group(5.81%, 5/86) was significantly lower than that in control group(30.23%, 26/86)( χ2=19.210, P<0.01). The serum 25-(OH)D level in intervention group was significantly higher than that in the control group ( t=13.425, P=0.018), while the levels of CRP, PCT and IL-6 in intervention group were significantly lower than those in control group ( t=17.312, 10.353 and 12.218, P<0.01 or <0.05). Conclusion:Vitamin D adjuvant therapy can increase serum 25-(OH)D level, decrease serum CRP, PCT and IL-6 levels, and effectively reduce the incidence of SBP in patients with decompensated cirrhosis of hepatitis B.
