"Shapeshifter of the mycobacterial world" : Discuss the mechanism of morphological transformation of Mycobacterium abscesses
10.3760/cma.j.issn.1674-2397.2023.03.006
- VernacularTitle:"分枝杆菌世界的变形者"：谈谈脓肿分枝杆菌形态转换机制
- Author:
Qing LI
1
;
Yuanyuan SHANG
;
Weicong REN
;
Yu PANG
Author Information
1. 首都医科大学附属北京胸科医院细菌免疫室 北京市结核病胸部肿瘤研究所 101149
- Keywords:
Mycobacterium abscessus;
Morphological transformation;
Phenotypic plasticity;
Glycopeptidolipid;
Mechanism
- From:
Chinese Journal of Clinical Infectious Diseases
2023;16(3):195-201
- CountryChina
- Language:Chinese
-
Abstract:
Mycobacterium abscessesus (MAB) is the most common species of rapidly growing pathogenic nontuberculous mycobacteria (NTM). MAB is also an opportunistic pathogen with high drug resistance. The unique structure of cell wall enables it to exist in different forms and to undergo morphological transformation, making it the "shapeshifter of the mycobacterial world" , which facilitates its survival in natural environment in a saprophytic manner; and also facilitates its invasion into the host with long-term survival and being pathogenic. This article reviews research progress on the specific deformability of MAB and the mechanism associated with its phenotypic transformation; discusses the evolutionary characteristics of MAB to adapt environmental changes to provide reference for better understanding the biological characteristics and pathogenicity of MAB.
