Clinical characteristics and antiviral therapy of influenza in immunosuppressed hospitalized patients
10.3760/cma.j.issn.1674-2397.2023.02.005
- VernacularTitle:免疫抑制住院患者流感病毒感染的临床特征及抗病毒治疗分析
- Author:
Yafen LIU
1
;
Yue WANG
;
Yanxin WANG
;
Huan MAI
;
Yuanyuan CHEN
;
Yifan ZHANG
;
Baiyi LIU
;
Yisi LIU
;
Ying JI
;
Xu CONG
;
Yan GAO
Author Information
1. 北京大学人民医院感染科 100044
- Keywords:
Influenza;
Immunosuppression;
Malignancy;
Haemopoietic stem cell transplants;
Antiviral therapy
- From:
Chinese Journal of Clinical Infectious Diseases
2023;16(2):120-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyse the clinical characteristics and antiviral therapy in immunosuppressed hospitalized patients with influenza.Methods:The clinical data of 273 patients with positive influenza A or B virus nucleic acid admitted in Peking University People’s Hospital from November 2015 to March 2022 were retrospectively analyzed. Among them, 123 were immunosuppressed and 150 were non-immunosuppressed. The clinical characteristics and antiviral therapy in immunosuppressed patients with influenza were analyzed. SPSS 22.0 software was used to analyze the data.Results:Chemotherapy for malignancies was the most common cause of immunosuppression (61.8%, 76/123), followed by haemopoietic stem cell transplantation (24.4%, 30/123). The common symptoms were fever (93.5%, 115/123) and cough (41.5%, 51/123). The proportions of co-infections (22.8%, 28/123) and complications (43.9%, 54/123) in immunosuppressed hospitalized patients were higher than those in non-immunosuppressed patients ( χ2=9.365 and 7.496, both P<0.01). Compared with single drug therapy, combination of antiviral drugs did not shorten the fever time, negative conversion time of virus nucleic acid and the length of hospital stay, and reduce the death ( U/ χ2=312.5, 356.0, 749.5 and 0.185, all P>0.05). Compared to patients without corticosteroids use, the use of corticosteroids did not increase mortality in immunosuppressed patients ( χ2=2.508, P=0.113). Conclusions:Classical symptoms may be absent in immunosuppressed patients with influenza, and early detection of influenza virus is still an important means of early diagnosis. Co-infections and complications are more common in immunosuppressed influenza patients. Immunosuppressed influenza patients did not benefit from the combination of antiviral therapy.
