BRICS report of 2021: The distribution and antimicrobial resistance profile of clinical bacterial isolates from blood stream infections in China
- VernacularTitle:全国血流感染细菌耐药监测(BRICS)2021年度报告
- Author:
Yunbo CHEN
1
;
Jinru JI
;
Zhiying LIU
;
Chaoqun YING
;
Qing YANG
;
Haishen KONG
;
Jiliang WANG
;
Hui DING
;
Haifeng MAO
;
Yizheng ZHOU
;
Yan JIN
;
Yongyun LIU
;
Yan GENG
;
Yuanyuan DAI
;
Hong LU
;
Peng ZHANG
;
Ying HUANG
;
Donghong HUANG
;
Xinhua QIANG
;
Jilu SHEN
;
Hongyun XU
;
Fenghong CHEN
;
Guolin LIAO
;
Dan LIU
;
Haixin DONG
;
Jiangqin SONG
;
Lu WANG
;
Junmin CAO
;
Lixia ZHANG
;
Yanhong LI
;
Dijing SONG
;
Zhuo LI
;
Youdong YIN
;
Donghua LIU
;
Liang GUO
;
Qiang LIU
;
Baohua ZHANG
;
Rong XU
;
Yinqiao DONG
;
Shuyan HU
;
Kunpeng LIANG
;
Bo QUAN
;
Lin ZHENG
;
Ling MENG
;
Liang LUAN
;
Jinhua LIANG
;
Weiping LIU
;
Xuefei HU
;
Pengpeng TIAN
;
Xiaoping YAN
;
Aiyun LI
;
Jian LI
;
Xiusan XIA
;
Xiaoyan QI
;
Dengyan QIAO
;
Yonghong XIAO
Author Information
- Keywords: Gram-negative bacteria; Gram-positive bacteria; Drug resistance; Bacterial; Blood stream infection; National sacle; Resistance surveillance
- From: Chinese Journal of Clinical Infectious Diseases 2023;16(1):33-47
- CountryChina
- Language:Chinese
- Abstract: Objective:To report the results of national surveillance on the distribution and antimicrobial resistance profile of clinical bacterial isolates from bloodstream infections in China in 2021.Methods:The clinical bacterial strains isolated from blood culture from member hospitals of Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected during January 2021 to December 2021. Antibiotic susceptibility tests were conducted by agar dilution or broth dilution methods recommended by Clinical Laboratory Standards Institute (CLSI). WHONET 5.6 was used to analyze data.Results:During the study period, 11 013 bacterial strains were collected from 51 hospitals, of which 2 782 (25.3%) were Gram-positive bacteria and 8 231 (74.7%) were Gram-negative bacteria. The top 10 bacterial species were Escherichia coli (37.6%), Klebsiella pneumoniae (18.9%), Staphylococcus aureus (9.8%), coagulase-negative Staphylococci (6.3%), Pseudomonas aeruginosa (3.6%), Enterococcus faecium (3.6%), Acinetobacter baumannii (2.8%), Enterococcus faecalis (2.7%), Enterobacter cloacae (2.5%) and Klebsiella spp (2.1%). The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus aureus were 25.3% and 76.8%, respectively. No glycopeptide- and daptomycin-resistant Staphylococci was detected; more than 95.0% of Staphylococcus aureus were sensitive to ceftobiprole. No vancomycin-resistant Enterococci strains were detected. The rates of extended spectrum B-lactamase (ESBL)-producing isolated in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis were 49.6%, 25.5% and 39.0%, respectively. The prevalence rates of carbapenem-resistance in Escherichia coli and Klebsiella pneumoniae were 2.2% and 15.8%, respectively; 7.9% of carbapenem-resistant Klebsiella pneumoniae was resistant to ceftazidime/avibactam combination. Ceftobiprole demonstrated excellent activity against non-ESBL-producing Escherichia coli and Klebsiella pneumoniae. Aztreonam/avibactam was highly active against carbapenem-resistant Escherichia coli and Klebsiella pneumoniae. The prevalence rate of carbapenem-resistance in Acinetobacter baumannii was 60.0%, while polymyxin and tigecycline showed good activity against Acinetobacter baumannii (5.5% and 4.5%). The prevalence of carbapenem-resistance in Pseudomonas aeruginosa was 18.9%. Conclusions:The BRICS surveillance results in 2021 shows that the main pathogens of blood stream infection in China are gram-negative bacteria, in which Escherichia coli is the most common. The MRSA incidence shows a further decreasing trend in China and the overall prevalence of vancomycin-resistant Enterococci is low. The prevalence of Carbapenem-resistant Klebsiella pneumoniae is still on a high level, but the trend is downwards.
