Factors related to false negative results of interferon-γ release test in patients with confirmed pulmonary tuberculosis
10.3760/cma.j.issn.1674-2397.2022.06.004
- VernacularTitle:γ-干扰素释放试验在肺结核确诊患者中检测结果假阴性的影响因素分析
- Author:
Ling YE
1
;
Jianhua LAN
;
Min FANG
;
Shun WANG
;
Zhiyu WU
;
Shugen WU
;
Chunxian PENG
;
Weili LU
;
Tao LU
Author Information
1. 浙江中医药大学第二临床医学院，杭州 310053
- Keywords:
Tuberculosis, pulmonary;
Interferon-γ release assay;
Diagnosis;
Influencing factors
- From:
Chinese Journal of Clinical Infectious Diseases
2022;15(6):454-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the influencing factors related to false-negative results of interferon-γ release assay (IGRA) QFT-GIT in patients with confirmed pulmonary tuberculosis.Methods:Clinical data of 389 patients with bacteriologically confirmed pulmonary tuberculosis who underwent QFT-GIT in Quzhou Hospital Affiliated to Wenzhou Medical University between January 1 and December 31 2020 were retrospectively analyzed. Univariate and multivariate logistic regression were used to analyze the influencing factors related to the false-negative results of QFT-GIT.Results:Among 389 confirmed patients, 347 cases had positive QFT-GIT results and 42 cases had negative results. Univariate analysis showed that the false-negative results of QFT-GIT were associated with low BMI, reduced CD4 + T lymphocyte count, decreased lymphocyte count, increased C-reactive protein, negative sputum smear, anemia, diabetes mellitus, malignant tumor and sepsis ( P<0.05 or P<0.01). Multivariate conditional logistic regression analysis showed that BMI <18.5 kg/m 2( OR=1.585, 95% CI 1.076-2.336), complicated with diabetes( OR=5.157, 95% CI 2.340-11.365), malignant tumors ( OR=5.596, 95% CI 2.048-15.295)and sepsis ( OR=4.141, 95% CI 1.042-16.459) were independent risk factors for the false-negative results of QFT-GIT ( P<0.05 or P<0.01). Conclusion:When the pulmonary tuberculosis patients are extreme emaciation, complicated with diabetes, malignant tumor or sepsis, the QFT-GIT results will be false negative.
