Research progress of precise therapy for Helicobacter pylori infection

VernacularTitle:幽门螺杆菌感染精准治疗研究进展
Author: Xinying LI ¹ ; Xiaojuan GAO ; Xiaowen DOU ; Xiqiu YU ; Jinfeng WU ; Xiuming ZHANG
Author Information

1. 深圳大学第三附属医院医学检验科　518001
Keywords: Helicobacter pylori; Bacterial resistance; Precise therapy
From: Chinese Journal of Clinical Infectious Diseases 2022;15(5):388-394
CountryChina
Language:Chinese
Abstract: Helicobacter pylori (HP) infection is one of the most prevalent chronic bacterial infections in the world, which is closely related to the development of gastrointestinal diseases, such as chronic gastritis, gastroduodenal ulcer and gastric cancer. Empirical treatment of HP infection may lead to antibiotic resistance, adverse reactions and poor compliance. The decreased HP eradication rate is related to antibiotic resistance, HP converting to coccoid form and admission of proton pump inhibitors (PPI). The implementation of precise therapy can effectively enhance the HP eradication rate, through antibiotics selecting based on detection of drug sensitivity phenotype and drug resistance genes, reducing adverse drug reactions, increasing patient compliance, and rationally administrating PPI, etc. This article reviews the research progress of precision therapy for HP infection to provide reference for clinicians.