Development of fibroblast activation protein-targeted molecular probes in non-neoplastic diseases
10.3760/cma.j.cn321828-20220422-00125
- VernacularTitle:成纤维细胞激活蛋白靶向分子探针在非肿瘤性疾病中的研究进展
- Author:
Kui XU
1
;
Chongjiao LI
;
Yong HE
Author Information
1. 武汉大学中南医院核医学科,武汉 430022
- Keywords:
Antagonists and inhibitors;
Membrane proteins;
Fibroblasts;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(8):508-512
- CountryChina
- Language:Chinese
-
Abstract:
Fibroblast activation protein (FAP) is an important molecular marker of cancer-associated fibroblasts (CAFs). FAP is selectively expressed in more than 90% of epithelial carcinomas, but barely expressed in normal tissues. In recent years, a variety of radiolabeled molecular probes based on FAP inhibitor (FAPI) have been developed and used for imaging of malignant tumors. FAP is also highly expressed in some non-neoplastic diseases related to chronic inflammation and tissue remodeling, including arthritis, atherosclerosis, fibrosis of myocardial infarction, cirrhosis, and idiopathic pulmonary fibrosis. FAPI imaging shows a potential in these diseases. This paper reviews the current status of radionuclide labeled FAPI and the application of which in non-neoplastic diseases.