Research progress on isotope-exchange-based 18F-labeling methods
10.3760/cma.j.cn321828-20211120-00410
- VernacularTitle:基于同位素交换的 18F标记方法研究进展
- Author:
Shengji LYU
1
;
Zhongjing LI
;
Zijing LI
Author Information
1. 厦门大学公共卫生学院分子影像暨转化医学研究中心，厦门 361102
- Keywords:
Isotope labeling;
Fluorine radioisotopes;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(5):316-320
- CountryChina
- Language:Chinese
-
Abstract:
The application of isotope exchange can realize radiolabeling in partially aqueous media, proceed under mild reaction conditions, and exclude complex purification procedure. It is suitable for one-step labeling of sensitive biomolecules with clinical application potential. This review systematically introduces the 18F/ 19F isotope exchange reactions based on carbon and those non-carbon-based reaction centers including silicon, boron, phosphorus, sulfur, gallium and iron. Discussions of the effects on isotope exchange radiochemical yields and molar activities by different reaction types, and labeling conditions and substitute groups on classic labeled substrate are held where possible, as well as recent applications in using these methodologies to develop PET probes.
