Simulation method based on PET image for tail vein extravasation correction
10.3760/cma.j.cn321828-20220318-00079
- VernacularTitle:基于PET/CT图像的动物尾静脉渗漏校正方法
- Author:
Yuhao YAN
1
;
Zhiping YANG
;
Zhiyong QUAN
;
Yuhua GAO
;
Fei KANG
;
Jing WANG
Author Information
1. 空军军医大学第一附属医院核医学科，西安 710032
- Keywords:
Extravasation of diagnostic and therapeutic materials;
Positron-emission tomography;
Tomography, X-ray computed;
Mice
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(5):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for correction of tail vein extravasation based on PET images and to improve the accuracy of SUV.Methods:The simulation method was established by phantom on Nano PET/CT and images were reconstructed by a three-dimensional ordered-subsets exception maximum algorithm. PET images were analyzed by using the Interview Fusion 1.0 software. The optimal scanning time and the ROI delineated method were found. The accuracy of the simulation method was verified by comparing the activity of simulation method with the mice tail activity measured by the dose calibrator directly on Kunming (KM) mouse ( n=11). Using the simulation method, the impact of extravasation on SUV was proved. Independent-sample t test was used to analyze data. Results:Ten minutes was selected as the optimal scanning time and SUV max 42% threshold was selected as the ROI delineated method. The specific correction formula was as follows: actual activity=image activity/(4.48× V+ 77.05)×100 (0.3 MBq/ml≤leakage concentration<6.5 MBq/ml); actual activity=image activity/(6.65× V+ 71.10)×100 (6.5 MBq/ml
