Value of SPECT myocardial perfusion imaging and coronary flow reserve combined with coronary artery calcium score in the diagnosis of obstructive coronary artery disease
10.3760/cma.j.cn321828-20211123-00416
- VernacularTitle:SPECT心肌灌注显像及冠状动脉血流储备联合钙化积分诊断阻塞性冠心病的价值
- Author:
Lubing SUN
1
;
Jie ZHANG
;
Ying ZHANG
;
Liu YANG
;
Yaozhen LI
;
Pei LI
;
Yuankun GUO
;
Wenjing WU
;
Jian XIE
;
Jing CUI
Author Information
1. 阜外华中心血管病医院核医学科，河南省人民医院核医学科，郑州 450003
- Keywords:
Coronary disease;
Myocardial perfusion imaging;
Fractional flow reserve, myocardial;
Tomography, emission-computed, single-photon;
Tomography, X-ray compu
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(5):272-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the value of myocardial perfusion imaging (MPI) and coronary flow reserve (CFR) combined with coronary artery calcium score (CACS) in the diagnosis of obstructive coronary artery disease (CAD).Methods:From January 2019 to December 2020, 96 confirmed or suspective CAD patients (65 males, 31 females; age: 30-81 years) who completed rest/stress MPI, CFR and CACS defection in Fuwai Central China Cardiovascular Hospital were retrospectively analyzed. Coronary angiography (CAG) was used as the diagnostic standard to calculate the sensitivity and accuracy of MPI, CFR and MPI/CFR combined with CACS in the diagnosis of CAD. The χ2 test was used to compare the diagnostic efficiency of different methods. Results:The diagnostic sensitivity of MPI was 76.06%(54/71), and the accuracy was 75.00%(72/96), while the sensitivity increased to 97.18%(69/71; χ2=13.67, P<0.001) and the accuracy increased to 87.50%(84/96; χ2=4.92, P=0.020) with significant differences after combined with CACS. The sensitivity and accuracy of CFR were 91.55%(65/71)and 87.50%(84/96), which increased to 97.18%(69/71; χ2=2.12, P=0.137) and 89.58%(86/96; χ2=0.21, P=0.411) with no significant differences after combined with CACS. The sensitivity of MPI in the diagnosis of three-vessel CAD was 70.00%(21/30), which increased to 100%(30/30; χ2=7.75, P=0.004) after combined with CACS; while the sensitivity of MPI combined with CACS in the diagnosis of single-vessel and double-vessel CAD were not significantly improved ( χ2 values: 3.29, 1.51, P values: 0.114, 0.416). Conclusion:The combination of MPI and CACS can significantly improve the diagnostic efficiency of CAD, contributed by the improvement of the diagnostic sensitivity in three-vessel disease; whereas the diagnostic efficiency of CFR for CAD is not significantly improved after combined with CACS.
