Predictive value of metabolic tumor volume and total lesion glycolysis in 18F-FDG PET/CT imaging for prognosis in patients with extensive-stage small cell lung cancer
10.3760/cma.j.cn321828-20211124-00417
- VernacularTitle:18F-FDG PET/CT显像肿瘤代谢体积和病灶糖酵解总量对广泛期小细胞肺癌预后的预测价值
- Author:
Ping CHEN
1
;
Qingzhu WANG
;
Baoping LIU
;
Biao DU
;
Xinli XIE
;
Ruihua WANG
;
Xinyu WANG
Author Information
1. 郑州大学第一附属医院核医学科，郑州 450052
- Keywords:
Small cell lung carcinoma;
Positron-emission tomography;
Tomography, X-ray computed;
Fluorodeoxyglucose F18;
Prognosis;
Forecasting
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(5):263-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with extensive-stage small cell lung cancer (ES-SCLC).Methods:From March 2019 to June 2020, 69 patients (55 males, 14 females, age: 38-87 years) with ES-SCLC who underwent pretreatment 18F-FDG PET/CT in First Affiliated Hospital of Zhengzhou University were retrospectively enrolled. The variables including gender, age, smoking, weight loss, liver metastasis, bone metastasis, malignant effusion, SUV max of the primary tumor, whole-body MTV (wbMTV) and whole-body TLG (wbTLG) (including wbMTV 40%, wbTLG 40%, wbMTV 2.5 and wbTLG 2.5) were analyzed. The predictors of overall survival (OS) were analyzed by using Kaplan-Meier method (log-rank test). Results:Of 69 ES-SCLC patients, 43(62%) died and 26(38%) were still alive by the end of follow-up, with a median survival time of 15.0(95% CI: 11.7-18.3) months. Univariate analysis revealed that age ( χ2=4.53, P=0.033), bone metastasis ( χ2=18.05, P<0.001), liver metastasis ( χ2=27.94, P<0.001), wbMTV 2.5 ( χ2=3.98, P=0.046), and wbTLG 2.5( χ2=5.80, P=0.016) were significant predictors of OS. Conclusion:wbMTV 2.5 and wbTLG 2.5 are assosciated with OS and may provide some reference value for predicting the prognosis of ES-SCLC patients.
