Prognostic value of metabolic parameters measured by 18F-FDG PET/CT in patients with primary advanced cutaneous malignant melanoma

VernacularTitle:18F-FDG PET/CT代谢参数评估原发性皮肤恶性黑色素瘤晚期患者的预后
Author: Ruihe LAI ¹ ; Yue TENG ; Yiwen SUN ; Lianjun ZHAO ; Shoulin XU ; Chong JIANG
Author Information

1. 南京大学医学院附属鼓楼医院核医学科，南京　210008
Keywords: Melanoma; Skin; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18; Prognosis
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2023;43(4):221-225
CountryChina
Language:Chinese
Abstract: Objective:To investigate the prognostic value of metabolic parameters measured by 18F-FDG PET/CT in patients with primary advanced cutaneous malignant melanoma (CMM). Methods:A retrospective analysis was comprised of 42 patients with advanced CMM (15 males and 27 females; median age: 60.0 years) from Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School between June 2014 and December 2019. All patients were initially diagnosed by pathology, and underwent 18F-FDG PET/CT imaging. 18F-FDG PET/CT parameters including SUV max, SUV mean, total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) of metastatic lesions were measured. ROC curve analysis was performed to obtain the optimal cut-off values of those metabolic parameters for predicting progression-free survival (PFS) and over-all survival (OS). Patients were divided into different groups based on their metabolic parameters (≥cut-off values or