Imaging study of β-amyloid deposits in preclinical Alzheimer′s disease patients in communities of Shanghai
10.3760/cma.j.cn321828-20210420-00128
- VernacularTitle:上海社区临床前期阿尔茨海默病人群β－淀粉样蛋白沉积的影像学研究
- Author:
Mengjie WANG
1
;
Shasha XU
;
Donglang JIANG
;
Junpeng LI
;
Jianfei XIAO
;
Shuhua REN
;
Qi HUANG
;
Yihui GUAN
;
Xingmin HAN
;
Lin HUANG
;
Keliang CHEN
;
Fang XIE
;
Qihao GUO
Author Information
1. 复旦大学附属华山医院PET中心，上海 200235
- Keywords:
Alzheimer disease;
Cognitive dysfunction;
Amyloid;
Positron-emission tomography;
Ethylene glycols
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2023;43(1):20-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the β-amyloid (Aβ) deposition pattern of subjects with the preclinical Alzheimer′s disease (AD), community-derived amnestic mild cognitive impairment (aMCI) and normal cognition (NC) from communities of Shanghai.Methods:According to the inclusion and exclusion criteria, 273 subjects (104 males, 169 females; age (64.2±7.6) years) were recruited from Shanghai community and memory clinics from December 2018 to July 2020. All subjects underwent MRI, 18F-AV45 PET imaging and neuropsychological scale tests and were grouped into AD, aMCI and NC groups based on clinical diagnosis. Differences in demographic information, the neuropsychological scale tests′ scores and positive rate of Aβ deposition among each group were analyzed by one-way analysis of variance or χ2 test. Aβ deposition patterns of AD and MCI groups were analyzed at voxel level, and the differences of Aβ deposition among different groups were compared. Results:Among 273 patients, the positive rates of Aβ deposition in AD, aMCI and NC groups were 84.4%(38/45), 36.4%(20/55) and 23.1%(40/173), respectively ( χ2=58.37, P<0.001). Among AD, aMCI, NC and NC (Aβ-) groups ( n=132), the education years of AD group was the lowest ((9.7±4.6) years; F=8.86, P<0.001). In addition, there were significant differences in the scores of several neuropsychological scale tests among AD, aMCI, NC groups and NC (Aβ-) group ( F values: 27.68-235.50, all P<0.001). Compared with subjects in NC(Aβ-) group, the Aβ depositions in the aMCI and AD groups were widely distributed in the whole cerebral cortex; and AD group had higher Aβ deposition in bilateral frontal, parietal, temporal, occipital lobe, cingulate gyrus and precuneus than aMCI group. Conclusions:The positive rate of Aβ deposition in the preclinical AD population from the Shanghai community is obtained. There are significant different Aβ deposition patterns in subjects at different stages of AD.
