Effect of endocannabinoid system on senile osteoporosis
10.3760/cma.j.cn121113-20220702-00369
- VernacularTitle:内源性大麻素系统对老年骨质疏松症的影响
- Author:
Yujiong CHEN
1
;
Jiaqi ZHONG
;
Zhaoxiang PENG
Author Information
1. 宁波大学附属李惠利医院关节与运动医学科，宁波 315040
- Keywords:
Osteoporosis;
Cannabinoid receptor modulators;
Osteoblasts;
Osteoclasts
- From:
Chinese Journal of Orthopaedics
2023;43(3):197-204
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common disease of old age that affects millions of people worldwide. Besides, it has been a chronic disease difficult to treat in the elderly, so it is of great significance to develop new drugs for the treatment of senile osteoporosis. The endocannabinoid system contains cannabinoid ligands, endocannabinoid receptors, and enzymes required for the synthesis and degradation of endocannabinoids, which play an important role in bone metabolism. Preclinical studies using endocannabinoid system-based therapies in animal models and in vitro have shown that endocannabinoid systems can prevent senile osteoporosis and highlight their therapeutic potential for senile osteoporosis. In this paper, PubMed, ScienceDirect, CNKY, and Wanfang databases were searched for articles related to the endocannabinoid system and osteoporosis. This paper analyzed the pathogenesis of senile osteoporosis (such as calcium, active vitamin D3 deficiency or insufficiency, sex hormone deficiency, cell function decline and secondary to chronic diseases, etc.), and reviewed the various components of the endocannabinoid system and their application in osteoporosis by regulating bone homeostasis in recent years, providing a new direction for the clinical treatment of senile osteoporosis.
