Effect of preoperative TACE on the complications after hepatectomy for hepatocellular carcinoma: a propensity score matching analysis
10.3760/cma.j.cn113884-20230310-00075
- VernacularTitle:术前TACE治疗对肝细胞癌肝切除术后并发症影响的倾向性评分匹配研究
- Author:
Runhu LAN
1
;
Chao WANG
;
Jiayu SHI
;
Zhengwei HE
;
Yong LI
;
Fubin LIU
;
Chengxian WU
;
Xiaoyin YUAN
;
Awang DANZENG
;
Pingcuo CIREN
;
Binhao ZHANG
Author Information
1. 武汉科技大学附属天佑医院肝胆外科，武汉 430064
- Keywords:
Carcinoma, hepatocellular;
Hepatectomy;
Chemoembolization, therapeutic;
Propensity score;
Postoperative complications
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(7):510-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of preoperative transcatheter arterial chemoembolization (TACE) on postoperative complications after hepatectomy in patients with hepatocellular carcinoma (HCC) by propensity score matching analysis.Methods:Of 1 666 patients with HCC undergoing hepatectomy in Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology and Tianyou Hospital of Wuhan University of Science and Technology from March 2015 to March 2021 were retrospectively screened. Of 262 patients were enrolled, including 236 males and 26 females, aged (50.3±11.8) years. Of 131 patients were enrolled in both the single surgery group and the combined group (preoperative TACE + surgical resection). Factors affecting the complications after hepatectomy in patients with HCC were analyzed using univariate and multivariate logistic regression method.Results:After matching the propensity score, the incidence of postoperative complications in the single surgery group was 22.1% (29/131), lower than that in the combined group [41.2% (54/131), χ 2=11.02, P<0.001]. The incidence of bile leakage in the single surgery group [2.3% (3/131)] was also lower than that in the combined group [(9.2% (12/131), χ 2=5.73, P=0.017]. Multivariate logistic regression analysis showed that the combined group ( OR=2.43, 95% CI: 1.28-4.61, P=0.007) had an increased incidence of postoperative complications, so did patients with a preoperative alpha-fetoprotein > 400 μg/L, anatomic hepatectomy, long operation time, and hilar occlusion. Conclusion:Preoperative TACE could be a risk factor for postoperative complications in patients with HCC, especially for the postoperative biliary leakage.
