Research progress of stroma-targeted therapies for pancreatic ductal adenocarcinoma
10.3760/cma.j.cn113884-20221210-00458
- VernacularTitle:胰腺导管腺癌基质靶向疗法研究进展
- Author:
Tao QIN
1
;
Chenghao CUI
;
Yanwei WANG
;
Yurong LIANG
Author Information
1. 甘肃医学院附属医院肝胆外科，平凉 744000
- Keywords:
Pancreatic neoplasms;
Fibroblasts;
Extracellular matrix;
Angiogenesis
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(6):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Desmoplastic stroma of pancreatic ductal adenocarcinoma plays an important role in tumor progression and treatment resistance. Stroma-targeted therapies are therefore promising for clinical application and extensive related researches are undergoing. In this article, recent advances in stromal targeting strategies were reviewed from three perspectives: cancer-associated fibroblasts, extracellular matrix and angiogenesis, and an outlook for the future of this strategy was also provided.
