Research progress on the relationship between pancreatic exocrine insufficiency and intestinal microbiota in aging individuals

VernacularTitle:衰老个体胰腺外分泌功能不全与肠道菌群关系的研究进展
Author: Zhe JIANG ¹ ; Yulin GUO ; Shuo WANG ; Feng CAO ; Fei LI
Author Information

1. 首都医科大学宣武医院普通外科，北京　100053
Keywords: Exocrine pancreatic insufficiency; Aging; Gastrointestinal microbiome
From: Chinese Journal of Hepatobiliary Surgery 2023;29(3):237-240
CountryChina
Language:Chinese
Abstract: Pancreatic exocrine insufficiency (PEI) refers to insufficient or non-synchronous secretion of trypsin caused by various reasons, resulting in dyspepsia and other symptoms. Intestinal microbiota is a large number of microbiota on the surface of intestinal mucosa. Its main functions include intestinal immune function, forming intestinal biological barrier and participating in the regulation of nutrition and metabolism. Due to aging, some elderly people often have unexplained chronic pancreatic insufficiency, which is often characterized by unexplained weight loss and malnutrition. Several studies have shown that the composition of intestinal microbiota changes significantly with age. This article focuses on aging and its related PEI and then reviews its possible effects on intestinal microbiota, in order to provide a reference basis for individualized prevention and treatment strategies according to the changes of pancreatic exocrine function and microbiota in the elderly.