Progress of lipoxygenase in liver ischemia reperfusion injury
10.3760/cma.j.cn113884-20221027-00403
- VernacularTitle:脂氧合酶在肝脏缺血再灌注损伤中的研究进展
- Author:
Fei WANG
1
;
Wen HOU
;
Shuang YANG
;
Jiansen LU
;
Decheng CHEN
;
Wenjing XU
;
Lei LIU
Author Information
1. 南开大学医学院，天津 300071
- Keywords:
Lipoxygenase;
Reperfusion injury;
Inflammatory response;
Lipid peroxidation
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(3):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Liver ischemia reperfusion injury (IRI) is one of the main causes of liver dysfunction or functional failure after liver transplantation or liver resection. As the main organ of lipid metabolism, liver is closely related to lipid metabolic balance. Lipoxygenase is a non-heme iron-containing oxidases that oxidizes polyunsaturated fatty acids to produce hydroxy-eicosanotetraenoic acid. Lipoxygenase is excessively expressed during liver ischemia, causing lipid metabolic disorders. High expression of several proinflammatory cytokines induced by lipoxygenase during liver reperfusion. Lipid peroxidation induced by lipoxygenase leads to the production of lipid oxygen free radicals, which induces iron death mainly characterized by lipid peroxidation, thus affecting apoptosis and tissue damage. This review mainly introduces the latest progress of lipoxygenase in liver IRI.
