Study on the characteristics of 18F-flurodeoxyglucose uptake in the microenvironment of hepatic alveolar echinococcosis
10.3760/cma.j.cn113884-20220106-00011
- VernacularTitle:肝泡型棘球蚴病病灶微环境摄取氟代脱氧葡萄糖的特征研究
- Author:
Abulizi ABUDUAINI
1
;
Aini ABUDUSALAMU
;
Bo RAN
;
Tiemin JIANG
;
Ruiqing ZHANG
;
Qiang GUO
;
Xiaohong LI
;
Jian WANG
;
Chuanshan ZHANG
;
Renyong LIN
;
Hao WEN
;
Yingmei SHAO
;
Aji TUERGANAILI
Author Information
1. 省部共建中亚高发病成因与防治国家重点实验室 新疆医科大学第一附属医院肝胆包虫病外科，乌鲁木齐 830054
- Keywords:
Echinococcosis, hepatic;
Lesion microenvironment;
18F-flurodeoxyglucose;
Position emission tomography and computed tomography;
Surgery;
Tissue samplin
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(3):176-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate characteristics of the 18F-flurodeoxyglucose ( 18F-FDG) uptake intensity and ranges in distinct hepatic alveolar echinococcosis lesions. Methods:The clinical data of 39 patients with position emission tomography during Jan 2017 to Dec 2019 in the First Affiliated Hospital of Xinjiang Medical University were enrolled. Among them, there were 17 males and 22 females, aging from 15 to 65 years (median 34 years). Lesions were classified into six groups based on heterogenic scales of calcification and liquefaction: A. non-calcified and non-liquefied ( n=7); B. obvious calcified and non-liquefied ( n=7); C. partial calcified and partial liquefied( n=10); D. obvious calcified and partial liquefied ( n=5); E. partial calcified and subtotal liquefied ( n=5); F. obvious calcified and subtotal liquefied ( n=5). Tumor to background ratio (TBR) and width (W) of lesion infiltrative boundary were measured and calculated. Statistical comparison using Mann-Whitney U test as well as correlation analysis was performed. Results:TBR values [ M( Q1, Q3)] for each group were 4.40(3.66, 7.03), 2.55(1.69, 3.60), 3.73(3.37, 5.21), 2.90(2.75, 3.60), 3.80(3.49, 6.36), 2.49(2.21, 3.97), among which A>B, A>D, A>F, C>B, E>B ( U=3.0, 4.0, 4.5, 11.0, 5.0, all P<0.05); From the perspective of the calcification in each group, it was found that the lighter the calcification was, the greater the TBR value was. W values [ M( Q1, Q3)] for each group were [12.5(10.0, 19.5), 11.2(10.5, 12.5), 12.2(10.9, 13.2), 7.8(7.3, 9.3), 10.0(7.3, 13.4), 7.3(6.8, 7.6)] mm, among which A>D, A>F, B>D, B>F, C>D, C>F (all U=0, all P<0.05); According to the degree of calcification and liquefaction of lesions in each group, the lighter the calcification was, the greater the W value was; The heavier the liquefaction was, the smaller the W value was. A mild strength linear correlation has been observed between the TBR value and W value ( r=0.4136, P<0.05). Conclusions:Less calcification and liquefaction implicated higher 18F-FDG uptake intensity and wider range. Radical resection margins and tissue sampling should be individualized based on different lesion features in surgical treatment.
