Three Cases of Cerivastatin Induced Rhabdomyolysis in Diabetic Patients.
- Author:
Seong Su LEE
1
;
Yu Kyung CHO
;
Hea Lim KIM
;
Hoon Jun PARK
;
Mahn Won PARK
;
Min Seck CHOI
;
Kang Woo LEE
;
Yoon Sik CHANG
;
Byung Kee BANG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. ysc543@unitel.co.kr
- Publication Type:Case Report ; Clinical Trial
- Keywords:
Rhabdomyolysis;
Cerivastatin
- MeSH:
Creatine;
Diabetes Mellitus;
Diabetic Nephropathies;
Follow-Up Studies;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Hyperlipidemias;
Kidney Failure, Chronic;
Metabolism;
Muscle Weakness;
Muscular Diseases;
Myalgia;
Peritoneal Dialysis;
Rhabdomyolysis*
- From:Korean Journal of Nephrology
2001;20(6):1031-1038
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cerivastatin is novel HMG-CoA reductase inhibitors. Clinical trials showed no significant differences of serum creatine kiase between cerivastatin and placebo, and cerivastatin-induced myopathy was rarely reported. This beneficial effect of cerivastatin is thought to be related to the the dual pathway metabolism by hapatic CYP3A4 and 2C8. We here report three cases of rhabdomyolysis which is associated with cerivastatin therapy. Two patients had diabetes mellitus, and received cerivastatin(0.8 mg/day) for treating hyperlipidemia and the other patient had chronic renal failure due to diabetic nephropathy and has maintained peritoneal dialysis and received cerivastatin(0.4 mg/day). Within one month of cerivastatin treatment, those patients experienced myalgia or muscle weakness. At that time, laboratory findings including muscle enzyme level, and bone scan finding were compatible with rhadomyolysis. Under the impression of cerivastatin- induced rhabodmyolysis, cerivastatin was withdrwan, and conventional treatment for rhabdomyolysis was started. Clinical course was uneventful, and these patients were discharged with good general condition. In conclusion, cerivastatin is regarded as a safe drug as compared with other statins, but it also causes rhabdomyolysis. Careful history taking and regular follow-up of muscle enzyme levels would be necessary to detect cerivastatin-induced rhabdomyolysis.
