Application of laparoscopic radical cholecystectomy in the treatment of stage Ⅲ gallbladder cancer
10.3760/cma.j.cn113884-20221025-00399
- VernacularTitle:腹腔镜胆囊癌根治术在治疗Ⅲ期胆囊癌中的应用
- Author:
Jiayu SHI
1
;
Xuewei JIANG
;
Awang DANZENG
;
Fubin LIU
;
Zhengwei HE
;
Chengxian WU
;
Runhu LAN
;
Xiaoyin YUAN
;
Yi WANG
;
Chao WANG
;
Binhao ZHANG
Author Information
1. 武汉科技大学附属同济天佑医院肝胆外科，武汉 430064
- Keywords:
Gallbladder neoplasms;
Laparoscopy;
Open surgery;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(2):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical efficacy of laparoscopic radical cholecystectomy in the treatment of stage Ⅲ gallbladder cancer.Methods:The clinical characteristics and postoperative follow-up data of 184 patients (male 66, and female 118) who underwent radical cholecystectomy for stage Ⅲ gallbladder cancer at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, from May 2015 to May 2022, were retrospectively analyzed. The age was (67.0±8.6) years old (range 38 to 85 years old). There were 71 patients in the laparoscopic group and 113 in the open group. The general medical data, surgery-related indicators and complications were analyzed. Follow-up was completed by outpatient visits and by telephone.Results:The laparoscopic group showed better postoperative alanine aminotransferase [67.5 (40.0, 138.5) vs. 104.0 (45.0, 252.2) U/L] and aspartate aminotransferase [41.5 (26.0, 71.2) vs. 53.0 (30.2, 153.5) U/L] recovery, higher albumin levels [32.05 (30.18, 35.20) vs. 30.50 (27.70, 33.50) g/L], earlier abdominal drainage tube removal [8.00(6.00, 10.25) vs. 10.00(6.00, 13.00)d], shorter hospital stay [10.00(8.00, 15.25) vs. 14.00(9.00, 19.00) d] and lower incidences of complications [(14.1%(10/71) vs. 31.9%(36/113)] when compared with the open group (all P<0.05). The 1 year (49.1% vs 61.0%), 2 years (24.0% vs. 28.5%), 3 years (16.0% vs. 14.5%) overall survival ( P=0.640), and the 3 years progression-free survival (18.3% vs. 15.0%, P=0.463) showed no significant difference between the 2 groups. Conclusion:Laparoscopic surgery for AJCC TNM stage Ⅲ gallbladder cancer showed comparable results with open surgery. When compared with open surgery, laparoscopic radical resection of gallbladder cancer had the advantages of earlier removal of abdominal drainage tube, lower incidence of postoperative complications, and shorter hospital stay.
