Minimal Change Nephrotic Syndrome Associated with Mesalazine Treatment in a Patient with Ulcerative Colitis.
- Author:
Jong Oh YANG
1
;
Sung Eun KIM
;
Sang Ju LEE
;
Ki Hyun PARK
;
Yun Kyung JANG
;
Kwang Sun SUH
;
Kang Wook LEE
;
Young Tai SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, Chungnam National University, Taejon, Korea. ytshin@hanbat.chungnam.ac.kr
- Publication Type:Case Report
- Keywords:
Mesalazine;
Minimal change disease;
Ulcerative colitis;
Proteinuria;
Prednisolone
- MeSH:
Acute Kidney Injury;
Adult;
Amyloidosis;
Biopsy;
Colitis, Ulcerative*;
Edema;
Glomerulonephritis;
Humans;
Inflammatory Bowel Diseases;
Kidney;
Mesalamine*;
Nephritis, Interstitial;
Nephrolithiasis;
Nephrosis, Lipoid*;
Nephrotic Syndrome;
Prednisolone;
Proteinuria;
Sulfasalazine;
Ulcer*
- From:Korean Journal of Nephrology
2001;20(6):1039-1042
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mesalazine has been widely prescribed for the treatment of inflammatory bowel disease. In renal disease associated with inflammatory bowel disease, nephrolithiasis and amyloidosis are most common, and obstructive uropathy, acute renal failure, glomerular abnormalities and interstitial nephritis due to drug may be occur. However, glomerulonephritis presenting as nephrotic syndrome in patients with ulcerative colitis is very rare. We present a case of minimal change nephrotic syndrome probably associated with mesalazine treatment in patient with ulcerative colitis. A 31-year-old man was admitted with generalized edema and proteinuria. He had been initially treated by sulphasalazine and then received mesalazine for 6 months, recently. Kidney biopsy revealed minimal change disease. Mesalazine was discontinued immediately and prednisolone(1 mg/kg, P.O.) was prescribed. Eight weeks after prednisolone treatment, proteinuria disappeared and patient recovered completely.