Clinical effect of different application times of antibiotics in patients with hypertriglyceridemic severe acute pancreatitis
10.3760/cma.j.cn113884-20221003-00380
- VernacularTitle:高甘油三酯血症性重症急性胰腺炎患者不同时机使用抗生素治疗的临床效果分析
- Author:
Lin HE
1
;
Yun SUN
;
Lijun CAO
;
Zhonghua LU
;
Pinjie ZHANG
;
Guangwei XIE
;
Xiaocong ZHOU
Author Information
1. 安徽医科大学第二附属医院重症医学一科，合肥 230601
- Keywords:
Pancreatitis;
Hypertriglyceridemia;
Anti-bacterial agents
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(12):913-917
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical effect of different application times of antibiotics in patients with hypertriglyceridemic severe acute pancreatitis(HTG-SAP).Methods:The clinical data of 92 patients with HTG-SAP who were treated at the Department of Critical Care Medicine of the Second Affiliated Hospital of Anhui Medical University from January 2016 to February 2022 were analyzed retrospectively. There were 65 males and 27 females, aged (40.82±10.55) years old. These patients were divided into three groups based on the time of prophylactic use of antibiotics: the early prevention group (used within 72 h after admission, n=39), the delayed prevention group (used after 72 h after admission, n=30) and the nonprevention group ( n=23). The clinical data such as the general data, length of stay and all cause mortality rate of the three groups of patients were analyzed. Results:Compared with patients in the nonprevention group, the incidence rate of pancreatic/peripancreatic infection [10.0%(3/30) vs. 39.1%(9/23)] and the incidence rate of bloodstream infection [6.7%(2/30) vs. 34.8%(8/23)] in the delayed prevention group were significantly decreased (pancreas/peripancreatic infection: χ 2=6.31, P=0.012; bloodstream infection: χ 2=6.72, P=0.010). The infection rate of multiple/pan resistant bacteria in the early prevention group [23.1%(9/39)] was significantly higher than the nonprevention group [4.3%(1/23)] (χ 2=4.49, P=0.034). There were no significant differences in the all cause mortality rate, length of stay, duration of intensive care, hospitalization cost, incidence of intestinal fistula and retroperitoneal hemorrhage, and the proportion of patients requiring surgery among the 3 groups (all P>0.05). Conclusions:Pophylactic use of antibiotics within 72 h of hospital admission significantly reduced the incidence of pancreatic/peripancreatic infection and bloodstream infection in patients with HTG-SAP. There were no significant differences in the final prognosis among these patients with HTG-SAP treated with antibiotics at different times.
