Research progress on the bone-marrow sparing intensity-modulated radiotherapy for cervical cancer
10.3760/cma.j.cn113030-20220606-00201
- VernacularTitle:宫颈癌骨髓保护调强放疗的研究进展
- Author:
Jia'nan WANG
1
;
Xi YU
;
Qiuyue SU
;
Dongmei LIU
;
Jingqi XIA
;
Shanshan YANG
Author Information
1. 哈尔滨医科大学附属肿瘤医院妇科放疗，哈尔滨 150081
- Keywords:
Uterine cervical neoplasms;
Concurrent chemoradiotherapy;
Bone marrow sparing;
Intensity-modulated radiation therapy;
Research progress
- From:
Chinese Journal of Radiation Oncology
2023;32(8):731-735
- CountryChina
- Language:Chinese
-
Abstract:
The cisplatin-based concurrent chemoradiotherapy (CCRT) has been accepted as a standard treatment for most locally advanced cervical cancer. Compared with radiation therapy alone, CCRT can increase tumor control and survival rates, whereas it also can increase the incidence of acute hematological toxicity, which results in the treatment interruption or delay, and may even affect clinical efficacy and prognosis of patients. Therefore, how to reduce the incidence and severity of acute hematological toxicity induced by CCRT is a hot spot of clinical research. Previous studies have demonstrated that the occurrence of hematological toxicity is associated with the volume and dose of irradiated pelvic bone marrow. With the development of modern radiotherapy technology, precise radiotherapy technologies, such as intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT), not only guaranteed the enough dose for tumor, but also realized the protection of normal tissues. This article will focus on the feasibility of bone marrow sparing during CCRT for cervical cancer, and summarize the research progress in recent years.
