Meta-analysis of the efficacy and adverse reactions of fractionated high dose rate brachytherapy as monotherapy for localized prostate cancer
10.3760/cma.j.cn113030-20221010-00336
- VernacularTitle:单纯高剂量率近距离治疗前列腺癌疗效及不良反应meta分析
- Author:
Wei GUO
1
;
Yunchuan SUN
;
Hongling LU
;
Xiaoming YIN
;
Xinying HE
;
Yiran ZHANG
;
Kui FAN
Author Information
1. 河北省沧州中西医结合医院放疗科，沧州 061000
- Keywords:
Prostatic neoplasms;
High dose rate brachytherapy;
Treatment outcome;
Adverse effects;
Meta-analysis
- From:
Chinese Journal of Radiation Oncology
2023;32(7):599-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To conduct a meta-analysis to analyze the efficacy and adverse reactions of fractionated high dose rate brachytherapy (HDR-BT) as monotherapy for localized prostate cancer.Methods:Relevant databases were searched to collect the clinical trials on HDR-BT as monotherapy in patients with localized prostate cancer. Included studies were limited to full-text publications of fractionated HDR-BT as monotherapy with a median follow-up of at least 5 years, and adequate reporting of treatment outcomes and adverse reactions data. Stata 12.0 was used for data analysis.Results:According to the inclusion and exclusion criteria, a total of 11 clinical trials involving 2 683 patients with prostate cancer were included in this meta-analysis. The results of the meta-analysis showed that 5-year biochemical recurrence-free survival (bRFS) rate and overall survival (OS) rate were 94% (95% CI: 93% - 96%) and 96% (95% CI: 94% - 98%), respectively. Long-term (≥5 years) cancer-specific survival (CSS) rate and distant metastasis-free survival (DMFS) rate were 99% (95% CI: 98% - 100%) and 98% (95% CI: 98% - 99%), respectively. Long-term (≥5 years) late grade ≥3 grade gastrointestinal and genitourinary adverse reactions rates were 2% (95% CI: 1% - 3%) and 9% (95% CI: 6% - 13%), respectively. Conclusions:Fractionated HDR-BT as monotherapy is an effective treatment for patients with localized prostate cancer. Its long-term efficacy is encouraging, and the treatment is well tolerated and safe.
