Recent progress on cGAS-STING pathway in tumor radiotherapy

VernacularTitle:cGAS-STING通路在肿瘤放射治疗中的研究进展
Author: Jieping QIU ¹ ; Jingjing CHENG ; Yawei BAO ; Jun XU ; Jieyong TIAN ; Dong QIAN
Author Information

1. 中国科学技术大学附属第一医院（安徽省立医院）肿瘤放疗科，合肥　230001
Keywords: cGAS-STING pathway; Radiotherapy; Immunotherapy
From: Chinese Journal of Radiation Oncology 2023;32(5):488-492
CountryChina
Language:Chinese
Abstract: Radiotherapy is widely used in the treatment of primary and metastatic malignant tumors. It is traditionally believed that the killing effect of radiotherapy on tumor is based on the direct or indirect damage of ionizing radiation to DNA. In recent years, the anti-tumor role and mechanism of anti-tumor immune response induced by ionizing radiation have captivated widespread attention and achieved significant progress. Among them, Cyclic GMP-AMP synthase (cGAS)-stimulator of interference genes (STING) pathway is considered to be one of the key regulatory hubs. cGAS is a cytoplasmic DNA receptor that can bind to tumor-derived double-stranded DNA and activate the downstream STING, thereby activating anti-tumor immune response of the host. In view of the latest progress in this field, the important role and potential mechanism of cGAS-STING pathway in radiotherapy immune effect were mainly summarized, and the application prospect of targeting cGAS-STING pathway in radiotherapy sensitization was explored.