Correlation between acute intestinal toxicity and dose-volume parameters in patients with cervical cancer receiving postoperative adjuvant radiotherapy
10.3760/cma.j.cn113030-20210928-00380
- VernacularTitle:宫颈癌术后放疗急性肠道不良反应与剂量-体积参数相关性
- Author:
Bichun XU
1
;
Qi GUO
;
Jianjun QIAN
;
Shang CAI
;
Ye TIAN
Author Information
1. 苏州大学附属第二医院放疗科/苏州大学放射肿瘤治疗学研究所/苏州市肿瘤放射治疗学重点实验室，苏州 215004
- Keywords:
Uterine cervical neoplasms;
Radiotherapy, intensity-modulated;
Adverse reaction, intestinal;
Dose-volume parameters
- From:
Chinese Journal of Radiation Oncology
2023;32(3):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify dose-volume parameters to predict the incidence of acute intestinal toxicity in cervical cancer patients after postoperative adjuvant radiotherapy.Methods:Clinical data of 93 cervical cancer patients who underwent postoperative adjuvant intensity-modulated radiotherapy (IMRT) were retrospectively evaluated. The dose-volume parameters comprised the absolute volume of the bowel receiving 5-45 Gy (5 Gy interval) radiation dose and the total volume of the bowel. The acute radiation-induced intestinal toxicity was evaluated by Radiation Therapy Oncology Group (RTOG) criteria. The association between the irradiated bowel volume and acute intestinal toxicity was analyzed.Results:A total of 26 (28%) patients experienced grade ≥2 acute intestinal toxicity. A strong relationship between grade ≥2 acute intestinal toxicity and the irradiated small bowel volume was observed at the total volume of small bowel, small bowel V 5 Gy, V 10 Gy and V 15 Gy (all P<0.05). Small bowel V 10 Gy ( HR=1.028, 95% CI, 0.993-1.062, P=0.029) and small bowel ?V 15 Gy( HR=0.991, 95% CI, 0.969-1.013, P=0.034)were the independent risk factors for evident acute intestinal toxicity. Conclusion:Dose-volume parameters of the small bowel can be used as predictors for the occurrence of grade ≥2 acute intestinal toxicity in cervical cancer patients undergoing postoperative adjuvant radiotherapy.
