Neck contour changes and relevant factors in nasopharyngeal carcinoma patients treated with helical tomotherapy
10.3760/cma.j.cn113030-20220330-00116
- VernacularTitle:鼻咽癌螺旋断层放射治疗中颈部轮廓变化及相关因素分析
- Author:
Huilang HE
1
;
Shuxian CHEN
;
Xuanguang CHEN
;
Zixian ZHANG
;
Jindi LIU
;
Wenyan YAO
;
Hui LIU
Author Information
1. 中山大学肿瘤防治中心 华南肿瘤学国家重点实验室 广东省鼻咽癌诊治研究重点实验室放射治疗科，广州 510060
- Keywords:
Nasopharyngeal carcinoma;
Helical tomotherapy;
Neck
- From:
Chinese Journal of Radiation Oncology
2023;32(2):106-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the change pattern of neck diameter and relevant factors in nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy, aiming to provide reference for clinical practice.Methods:Fifteen NPC patients treated with helical tomotherapy at Sun Yat-Sen University Cancer Center from November 2020 to February 2021 were enrolled in this study. The transverse diameters of NPC patients' neck contours and body weight of all patients during radiotherapy were recorded weekly. We used descriptive statistics to explore the distribution of transverse diameters of NPC patients' neck contours during radiotherapy. And Spearman correlation analysis was used to assess the association between weight loss and changes in neck contour transverse diameter.Results:During radiotherapy, the distribution of transverse diameters of NPC patients' neck contours was completely different from the initial values. Specifically, the transverse diameters were significantly reduced at the 4th week of the radiotherapy. Moreover, the reduction of transverse diameter of neck contour was highly correlated with the weight loss ( r=0.803, P<0.05), and moderately correlated with gender ( r=0.523, P<0.05). However, there was no statistical correlation between the alteration of neck diameter and age, TNM stage, and the mean dose of GTV nd-L, GTV nd-R, PTV nd-L and PTV nd-R (all P>0.05). Conclusions:The neck contours of NPC patients are altered regularly during helical tomotherapy, which are narrowed the most obviously in the 4th week. Extensive attention should be paid to the changes of neck contour during radiotherapy in clinical practice.
