Recent advances in hippocampal sparing whole brain radiotherapy
10.3760/cma.j.cn113030-20211009-00388
- VernacularTitle:海马保护在全脑放疗中的研究进展
- Author:
Zhongxuan GUI
1
;
Tingting HAN
;
Fan WANG
Author Information
1. 安徽医科大学第一附属医院放疗科，合肥 230022
- Keywords:
Neoplasm metastasis, brain;
Whole-brain radiotherapy;
Neurocognitive function;
Hippocampal protection
- From:
Chinese Journal of Radiation Oncology
2023;32(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Whole brain radiotherapy (WBRT) is the standard radiotherapy regimen of preventive radiation for patients diagnosed with brain metastases and non-small cell lung cancer, which can improve intracranial control and prolong overall survival. However, neurocognitive functions (NCF) decline due to impaired hippocampal might occur thereafter. Recent studies have shown that hippocampal sparing WBRT (HS-WBRT) is capable of protecting neurocognitive function and improving quality of life (QOL). In this review, the authors described the methods and significance of hippocampal sparing, summarized the research progress on clinical trials related to HS-WBRT in combination with the development of radiotherapy technology and experimental drugs, and discussed the existing controversies and problems, aiming to provide reference for clinical work.
