Efficacy and safety of intraoperative radiotherapy for pancreatic cancer: a meta-analysis
10.3760/cma.j.cn113030-20220510-00166
- VernacularTitle:术中放疗应用于胰腺癌的疗效与安全性meta分析
- Author:
Lei CAO
1
;
Daxiong YANG
;
Lu ZENG
;
Lili LIN
;
Huixia WANG
;
Xiaoyu DUAN
;
Xuxia LI
;
Hongyi CAI
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Pancreatic neoplasms;
Intraoperative radiotherapy;
Surgery;
Meta-analysis
- From:
Chinese Journal of Radiation Oncology
2023;32(1):22-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare and analyze the efficacy and safety of intraoperative radiotherapy (IORT) combined with conventional therapy (surgery combined with radiochemotherapy) and conventional therapy alone for pancreatic cancer.Methods:Literature review was conducted from PubMed, Cochrane Library, Web of Science, Embase, Chongqing VIP, CNKI, Wanfang Data and China Biomedical Literature Service System (SinoMed). The literatures that met the inclusion criteria were screened and the data were extracted. Meta-analysis was carried out by RevMan 5.4 software.Results:A total of 11 studies consisting of 813 patients were included. According to the combined results, compared with conventional therapy, IORT combined with conventional therapy could improve the overall survival rate of pancreatic cancer ( HR=0.66, 95% CI=0.54-0.81, Z=4.03, P<0.001), and did not increase the treatment-related side effects ( OR=1.00, 95% CI=0.69-1.46, Z=0.01, P=0.99), but failed to bring benefit to the local control rate ( HR=0.56, 95% CI=0.31-1.01, Z=1.93, P=0.05). Conclusions:The overall survival rate in the IORT combined with conventional therapy group is significantly better than that in the conventional therapy group. No significant difference is found in the treatment-related adverse reactions between two groups. IORT combined with conventional therapy is worthy of clinical application.
