Research progresses in the radiotherapy effect on ovarian function and its protection
10.3760/cma.j.cn112271-20230307-00063
- VernacularTitle:放射治疗对卵巢功能影响的机制及防护研究进展
- Author:
Yike YU
1
;
Jicong DU
;
Lan FANG
;
Jianyi ZHANG
;
Shengyun CAI
Author Information
1. 海军军医大学附属长海医院妇产科，上海 200433
- Keywords:
Radiotherapy;
Ovarian injury;
Secondary ovarian insufficiency;
Reproductive function;
Fertility preservation
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(6):483-488
- CountryChina
- Language:Chinese
-
Abstract:
The survival rate of cancer patients was improved due to the development of cancer treatment techniques, and thus the fertility protection for young female cancer patients has attracted increasing attention. Radiotherapy, as one of the comprehensive cancer treatment, could cause ovarian damage in adolescent and child-bearing women, which leads to fertility decline and a series of side effects. Radiation can cause ovarian damage not only by acting on biological macromolecules directly, but also by increasing oxidative stress between oocytes and ovarian granulosa cells indirectly. At present, the fertility preservation of female cancer patients undergoing radiotherapy mainly includes physical protection, drug protection and biological protection. Recently, the development of new technologies for the preservation of fertility in female cancer patients has also brought new hope, including factors such as protective effects, patient age, and the selection of specific cancer treatment measures, which are the main considerations in the selection process of fertility preservation measures. This article reviews the research progress on radiation-induced ovarian damage, with a focus on the introduction of the fertility preservation measures and new technologies for young female tumor patients receiving radiotherapy.
