Research progress of the mechanism of Flash effect

VernacularTitle:Flash效应机制研究进展
Author: Wanyi ZHOU ¹ ; Ankang HU ; Rui QIU ; Junli LI
Author Information

1. 清华大学工程物理系　粒子技术与辐射成像教育部重点实验室，北京　100084
Keywords: Flash radiotherapy; Mechanism; Hypothesis
From: Chinese Journal of Radiological Medicine and Protection 2023;43(2):143-148
CountryChina
Language:Chinese
Abstract: The ultra-high dose rate (UHDR) radiation has less side effect while keep comparable tumor control effect with conventional dose rate (CONV) radiation, which was named Flash effect. Recently, the Flash effect has been reported in many animal experiments with various types of radiations, animal species and body parts. However, the underlying mechanism of Flash has still been unraveled, making difficulties for the clinical application. This review pointed out the differences between the Flash effect and the UHDR effect in vitro and proposed three key scientific questions of Flash effect based on three well-known hypotheses, i. e., oxygen depletion, peroxyl radical recombination and immune cell protection. Finally, the research progresses and challenges of Flash mechanism study are concluded in order to give a clue for further deep investigation.