Experimental study of percutaneous transhepatic implantation of recoverable fiducial marker in Cyberknife tracking therapy
10.3760/cma.j.cn112271-20221108-00440
- VernacularTitle:经皮肝穿刺植入可回收金标在射波刀追踪治疗的实验研究
- Author:
Xianzhi DENG
1
;
Jing CHEN
;
Zhanghua LIN
;
Nuoxi LI
;
Fangfen DONG
;
Shanting HE
;
Jianping ZHANG
;
Benhua XU
;
Jiajun MA
;
Xiaobo LI
Author Information
1. 福建医科大学医学影像学院 福建医科大学肿瘤中心 福建省肿瘤智能影像与精准放疗重点实验室 福建省消化、 血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心，福州 350001
- Keywords:
Recoverable fiducial marker;
Percutaneous transhepatic implantation;
Cyberknife;
Rabbit
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(2):81-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the feasibility of a novel liver fiducial marker implantation method for internal fixation and removal of rabbit livers, in order to use in Cyberknife tracking therapy.Methods:Experiments were conducted in vivo and in vitro. In the in vivo experiment, three fiducial markers were implanted percutaneously in each liver of ten rabbits under anesthesia, and the fourth fiducial marker with an external catheter and fixed thin wire was implanted ten days later. After the reference group (the first and the second maker), and the casing group (the first and the fourth marker) were respectively registered and tracked with the Cyberknife, the implantation success rate, registration accuracy, and removal safety of fiducial markers were assessed. The tensile test was performed using liver in vitro by measuring the resistance required to dislodge the spring coil fiducial markers and the fiducial markers without spring coil from liver. Results:The intrahepatic catheter implantation and removal of fiducial marker in rabbit liver had a success rate of 100% and no distant migration. The operation-related and postoperative complications were not occurred. All fiducial markers were successfully traced. Compared to the reference group, the casing group had slightly higher translational errors in supero-inferior and antero-posterior directions ( Z=-11.77, -4.57, P<0.05), and lower translational errors in left-right direction ( Z=-2.52, P<0.05). The dislodgement forces for spring coil fiducial markers was (2.23±0.85) N, significantly different with (0.81±0.13) N for fiducial markers without spring coil ( Z=- 2.31, P < 0.05). Conclusions:The spiral coil structure provides superior fixation in the punctured needle channel, the thin line limits the distant displacement of the fiducial marker outside the liver, and the catheter establishes a channel for the removal. The general operation is simple and easy.
