Research progress in gold nanoclusters for radiosensitization

VernacularTitle:金纳米簇放射治疗增敏作用的研究进展
Author: Fang DENG ¹ ; Sisi LIU ; Ruimin HE ; Huaxin TAN
Author Information

1. 南华大学附属第一医院病理科，衡阳　421000
Keywords: Radiotherapy; Radiation sensitizer; Gold nanoclusters
From: Chinese Journal of Radiological Medicine and Protection 2022;42(12):1010-1014
CountryChina
Language:Chinese
Abstract: Radiotherapy still fails to achieve satisfactory efficacy in the treatment of malignant tumors, and applying radiotherapy sensitizers is an effective method to improve the efficacy of radiotherapy. Gold nanomaterials can effectively increase the sensitivity of tumor cells to radiotherapy due to their high atomic numbers. Gold nanoclusters have more excellent radiobiological and radiophysical properties due to their smaller size. This paper reviews the special radiobiological and radiophysical properties of gold nanoclusters and describes in detail their sensitizing effects in external radiation radiotherapy, radionuclide therapy, and X-ray induced photodynamic therapy.