Radiation protection effect of furosemide intervention on 18F-FDG PET/CT imaging
10.3760/cma.j.cn112271-20220309-00089
- VernacularTitle:呋塞米介入对 18F-脱氧葡萄糖正电子发射计算机断层显像的放射防护作用
- Author:
Yin NI
1
;
Xiaoyan HU
;
Lanping HU
;
Nana LUO
;
Dasheng QIU
Author Information
1. 湖北省肿瘤医院核医学科，武汉 430079
- Keywords:
18F-2-deoxy-D-glucose;
Positron emission tomography/computed tomography;
Furosemide;
Peripheral dose equivalence rate
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(12):980-983
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the radiation protection effect of furosemide intervention on 18F-2-deoxy-D-glucose ( 18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging. Methods:A total of 146 patients were randomly divided into two groups, with test group of 74 patients and control group of 72. The test group was administrated orally with furosemide of 40 mg for each one before injection, while the normal control group did not undergo special treatment. 60 and 120 min after 18F-FDG injection, the horizontal measurement of ambient dose equivalent rates was carried out at 0.5 m from the front of both chest and abdomen respectively. Results:For the test group, the ambient dose equivalent rates were measured to be (30.80±8.61) and (41.38±11.06) μSv/h 60 min after injection of 18F-FDG whereas (18.26±4.85) and (24.66±6.50) μSv/h 120 min after injection, respectively, both lower than in the control group and with statistically significant difference between the both ( t =15.36, 13.13, 18.73, 17.29, P<0.05) . No significant difference was found between mediastinal SUV max and liver SUV max in the experimental group and control group ( P>0.05) . Multivariate ANOVA showed that body surface area was a major factor influencing ambient dose equivalent rate regardless of furosemide injection ( t=-13.52, 2.96, P<0.05) , and no obvious effects of age and sex on ambient dose equivalence rate were found. Conclusions:Furosemide intervention can promote urination, effectively reduce the internal radiation exposure of the examinated patietns in the premise of not affecting the image quality, and therefore provide a better radiation protection effect.
