Safety and efficacy of nimotuzumab combined with IMRT radiotherapy in the treatment of elderly patients with locally advanced cervical cancer
10.3760/cma.j.cn112271-20220906-00362
- VernacularTitle:尼妥珠单抗同步调强放射治疗对老年局部晚期子宫颈癌的安全性和有效性研究
- Author:
Yanhong ZHUO
1
;
Youjia WANG
;
Limin CHEN
;
Chunnuan ZHENG
;
Huiqin CHEN
;
Yimin LI
;
Pin JIANG
;
Junjie WANG
;
Yongbin LI
;
Jianli HUANG
Author Information
1. 福建医科大学附属漳州市医院肿瘤放射治疗科 漳州 363000
- Keywords:
Nimotuzumab;
Elderly;
Cervical cancer;
Concurrent chemoradiotherapy;
Safety
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(12):928-934
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the safety and efficacy of nimotuzumab combined with IMRT radiotherapy in the treatment of elderly patients with locally advanced cervical cancer (LACC).Methods:A retrospective analysis was conducted for 34 elderly LACC patients treated with nimotuzumab combined with IMRT radiotherapy or concurrent chemoradiotherapy in the Zhangzhou Affiliated Hospital of Fujian Medical University from June 2020 to December 2021. The efficacy and side effects were evaluated one and two years after treatment.Results:Median follow-up time was 13.3 months (6.1-24.3 months). A total of 24 cases of complete response (CR) and eight cases of partial response (PR) were achieved after treatment, with an objective response rate (ORR) of 94.1% (32/34). The tumor diameters were (49.56 ± 19.22) mm before treatment and (19.61 ± 14.59) mm after treatment, with a tumor regression rate (TRR) of 59.22%.The 1- and 2- year progression-free survival (PFS) rates were 84.9% and 84.9%, overall survival (OS) rates 91.8% and 87.2%, respectively, disease-free survival (DFS) rates 91.8% and 87.2%, respectively, and the cancer-specific survival (CSS) rates 95.7% and 90.9%, respectively. The main adverse events included radiation enteritis, leukopenia, hypoproteinemia and anemia.Conclusions:Nimotuzumab combined with IMRT radiotherapy or concurrent chemoradiotherapy is safe and effective in the treatment of LACC.
