Analysis of chromosome aberration in peripheral blood lymphocytes of underground miners in non-uranium metal mines
10.3760/cma.j.cn112271-20220901-00356
- VernacularTitle:非铀金属矿井下矿工外周血淋巴细胞的染色体畸变分析
- Author:
Di WU
1
;
Ping WANG
;
Lin HAN
;
Yanfang ZHAO
;
Zuchang ZHAO
;
Jie LI
;
Shasha DU
;
Xiai WANG
;
Yunfei ZHANG
;
Fengling ZHAO
;
Yumin LYU
Author Information
1. 河南省第三人民医院 河南省职业病医院 河南省辐射生物与流行病学医学重点实验室，郑州 450052
- Keywords:
Non-uranium metal mines;
Underground miners;
Peripheral blood lymphocytes;
Chromosomal aberrations
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(12):915-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate chromosomal aberrations in peripheral blood lymphocytes of underground miners, in order to explore the influencing factors involved in chromosomal aberration levels of non-uranium metal mines.Methods:Totall 135 workers were recruited from an iron mine and a gold mine located in different cities of Henan province, where 69 workers worked aboveground and 66 miners worked underground in the metal mines. The radon concentration in the mines was measured by solid-state nuclear track detectors. Chromosomal aberrations in peripheral blood lymphocytes from the subjects were detected using conventional analysis method, and the influence factors of chromosomal aberrations were analyzed.Results:Radon concentration was 30-2 943 Bq/m 3 in the aboveground workplace of the mines, and 62-28 314 Bq/m 3 in underground. The age of the underground group was obviously lower than that of the aboveground group( t=2.12, P<0.05), but the frequencies of dicentrics, translocation, acentric fragment, and total chromosome-type aberrations in the underground group were significantly higher than those in the aboveground group ( χ2=10.49, 16.74, 8.15, 29.50, P<0.01). Consistent results were obtained when only male workers were regarded as object of observation ( χ2=8.44, 11.63, 4.94, 20.81, P<0.05). The frequency of translocation ( χ2=8.44, P<0.05) was dependent on the length of service in the underground group. Poisson regression analysis indicated that the aboveground and undergroud grouping partly affected the levels of dicentrics, translocation, acentric fragment, and total chromosome-type aberrations (the underground group IRR=3.25, 2.69, 1.97, 2.18, P<0.05). Conclusions:The radon exposure in the underground workplace of the metal mines may be the main factor resulting in the increase of chromosome-type aberrations of miners. The occupational health and safety of the miners who may be exposed to high radon levels are worthy of great attention.
