Clinical features of patients with connective tissue disease combined with sarcoidosis
10.3760/cma.j.cn141217-20221020-00436
- VernacularTitle:结缔组织病合并结节病患者的临床特点
- Author:
Zhihong WAN
1
;
Qun SHI
;
Li WANG
;
Mengtao LI
;
Xiaofeng ZENG
;
Fengchun ZHANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科 国家皮肤与免疫疾病临床研究中心（NCRC-D2D），疑难重症及罕见病国家重点实验室，风湿免疫学教育部重点实验室，北京 100730
- Keywords:
Sarcoidosis;
Connective tissue diseases;
Sj?gren′s syndrome;
Dermatomyositis
- From:
Chinese Journal of Rheumatology
2023;27(5):304-308,C5-1
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features of patients with coexisting connective tissue disease (CTD) and sarcoisosis and to avoid misdiagnosis and mistreatment.Methods:To analyze the clinical manifestations, laboratory data, imaging and pathological features of patients with CTD combined with sarcoidosis in Peking Union Medical College Hospital from January 1985 to December 2021.Results:There were 17 patients with CTD(including 10 SS, 2 DM, 2 PBC, 1 SLE, 1 RA and 1 UCTD), combined with sarcoidosis, with a mean age of (55±10) years old and the ratio of male-to-female was 1:16. Eight patients were diagnosed as CTD before sarcoidosis, while 3 patients after sarcoidosis. The other 6 patients were diagnosed with the two diseases almost simultaneously. Lymphadenopathy(12/17), pulmonary nodules (8/17), subcutaneous nodules (4/17), rash (4/17) and blurred vision (1/17) were the main manifestations of patients with the onset of nodular disease. Nine patients were treated based on the presentation of sardoisis and 5 patients for CTD; 3 patients were treated for both diseases at the same time. All 17 patients discharged with improvement after treatment.Conclusion:When sarcoidosis do coexists with CTD, occult CTD might occur. It is important to investigate specific manifestations including pathological features of sarcoidosis and differentiate it from CTD.
