Clinical value of SLE-DAS in evaluating disease activity of systemic lupus erythematosus
10.3760/cma.j.cn141217-20220511-00197
- VernacularTitle:系统性红斑狼疮疾病活动评分评估系统性红斑狼疮疾病活动的临床价值研究
- Author:
Yang DONG
1
;
Lijiao WANG
;
Huixia CAO
;
Lei YAN
;
Zhu ZHANG
;
Fengmin SHAO
Author Information
1. 河南省人民医院肾内科 阜外华中心血管病医院肾内科 河南省肾病临床医学研究中心 河南省肾脏病免疫重点实验室 郑州大学阜外华中心血管病医院，郑州 451464
- Keywords:
Lupus erythematosus, systemic;
Disease activity;
Systemic lupus erythematosus disease activity score;
Systemic lupus erythematosus disease activity index
- From:
Chinese Journal of Rheumatology
2023;27(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic performance and clinical significance of SLE-DAS in the disease activity of SLE patients in China.Methods:The clinical data of 134 patients with SLE were collected. The disease activity was evaluated by SLE-DAS, SLEDAI-2000, BILAG-2004 and PGA scoring tools. Pearson test and Spearman test were used to analyze the correlation. The receiver operating characteristic curve (ROC curve) was used to evaluate SLE-DAS, and Kappa consistency test was adapted to assess the consistency of the two scoring methods.Results:One hundred and thirty-four patients with SLE, including 7 males and 127 females, aged 13-77 years, with an average of (35±13) years were included. Among them, renal involvement was 38.1%, skin mucosal involvement was 11.2%, musculoskeletal involvement was 8.2%, blood system involvement was 13.4%, heart and lung involvement was 2.2%, neuropsychiatric involvement was 1.5%, and multisystem involvement was 3.0%. SLE-DAS was positively correlated with CRP, ESR, anti-dsDNA antibody, urinary protein (24 h) level, SLEDAI-2000, BILAG-2004 and PGA ( r=0.25, 0.34, 0.47, 0.77, 0.93, 0.94, 0.95, P<0.01); SLE-DAS was negatively correlated with PLT, Hb, C3 and C4 ( r=-0.29, -0.43, -0.41, -0.32, P<0.01). When SLEDAI-2000>5 was used as a cut point for analyzing SLE-DAS, the results showed that the area under the curve (AUC) 95% CI of SLE-DAS was 0.961 (0.927,0.995), the Yoden index was 0.845. When the cut-off value was set up to 4.65( P<0.001), the sensitivity was 98.11%, the specificity was 86.42%, and the accuracy was 91.04%. Kappa consistency test showed that kappa value was 0.819( P<0.001). Conclusions:SLE-DAS can be used to evaluate the disease activity of SLE patients and can be used as the evidence to guide treatment plan in clinical practice.
