Analysis of reproductive outcomes in the first IVF-ET cycle after laparoscopic treatment in patients with endometriosis
10.3760/cma.j.cn112141-20220728-00488
- VernacularTitle:子宫内膜异位症患者腹腔镜手术后首次IVF-ET的治疗结局分析
- Author:
Qi ZHANG
1
;
Feng ZHOU
;
Lan LI
;
Xiaoni GUO
;
Jingwei YANG
;
Shubiao HAN
;
Xiaodong ZHANG
Author Information
1. 重庆市妇幼保健院 重庆医科大学附属妇女儿童医院生殖医学中心 人类胚胎工程重庆市重点实验室，重庆 400010
- Keywords:
Endometriosis;
Laparoscopy;
Fertilization, in vitro;
Embryo transfer;
Pregnancy outcome
- From:
Chinese Journal of Obstetrics and Gynecology
2023;58(2):91-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of endometriosis (EM) on reproductive outcomes of young patient with EM after laparoscopic treatment in the first in vitro fertilization-embryo transfer (IVF-ET) cycle.Methods:The clinical data and reproductive outcomes of 394 infertile patients with EM after laparoscopic treatment (EM group) and 3 242 infertile patients caused by gamete transport disorder (control group) in the first IVF-ET cycle were collected in Chongqing Health Center for Women and Children from January 2016 to June 2021. The information included baseline characteristics, oocyte retrieval, embryo development, clinical pregnancy, miscarriage, and live birth. Propensity score matching (PSM) method was used to perform 1∶2 matching between EM group and control group. The impact of EM on reproductive outcomes was analyzed in the retrospective observational study.Results:In the initial data, compared with control group, the number of two pronucleus (2PN) zygotes (9.7±4.8 vs 9.0±4.4), the number of transferable embryos (6.2±3.6 vs 5.5±3.4) and the rate of transferable embryos (64.0% vs 60.8%) on the third day were significantly lower in EM group, and the differences were statistically significant (all P<0.05). After PSM was performed, there were 394 and 787 cases in EM group and control group, respectively. Compared with control group, the number of 2PN zygotes (9.7±4.9 vs 9.0±4.4), the 2PN fertility rate (77.1% vs 75.3%), the number of transferable embryos on the third day (6.2±3.6 vs 5.5±3.4), the transferable embryos rate on the third day (63.8% vs 60.8%) were significantly lower in EM group, and the differences were statically significant (all P<0.05). The study did not find the effect of EM on embryo implantation rate, pregnancy rate, early miscarriage rate, live birth rate and preterm birth rate (all P>0.05). Conclusions:EM might interfere with the development of oocytes and embryos. Obtaining top-quality embryos may be an effective way to improve the prognosis of patients with EM after laparoscopic treatment.
