Correlation analysis of contrast-enhanced ultrasound Liver Imaging Reporting and Data System classification with hepatocellular carcinoma differentiation and Ki-67 index
10.3760/cma.j.cn131148-20230116-00032
- VernacularTitle:超声造影肝脏影像数据和报告系统分类与肝细胞癌分化程度及Ki-67指数的相关性分析
- Author:
Suwan CHAI
1
;
Wenjia CAI
;
Jie YU
;
Rongqin ZHENG
;
Jintang LIAO
;
Baoming LUO
;
Lina TANG
;
Ping LIANG
Author Information
1. 解放军医学院/解放军总医院，北京 100853
- Keywords:
Contrast-enhanced ultrasound;
Hepatocellular carcinoma;
Liver Imaging Reporting and Data System;
Degree of differentiation;
Ki-67 index
- From:
Chinese Journal of Ultrasonography
2023;32(5):386-391
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of hepatocellular carcinoma (HCC) classified by contrast-enhanced ultrasound (CEUS) Liver Imaging Data and Report System (LI-RADS) with differentiation degree and Ki-67 index.Methods:A multicenter, retrospective study was conducted.The clinical and CEUS imaging data of 208 patients with 208 HCC lesions from December 2017 to December 2020 in China CEUS database were included and analyzed. According to the CEUS LI-RADS version 2017 proposed by the American College of Radiology, the HCC was classified. The diagnosis and pathological information of all lesions were confirmed by pathology. The differentiation degree of HCC and the distribution of Ki-67 index in different LI-RADS categories were evaluated, and their correlation was analyzed.Results:The degree of differentiation and Ki-67 index among HCC of different CEUS LI-RADS were statistically significant ( P<0.001, P=0.009). LI-RADS M HCC was more likely to be poorly differentiated and showed a higher Ki-67 index. The category of LI-RADS was positively correlated with the degree of tumor differentiation (tau-b=-0.250, P<0.001) and the Ki-67 index (tau-b=0.178, P=0.002), that is, the higher the category of LI-RADS, the lower differentiation degree and the higher the Ki-67. Conclusions:The CEUS LI-RADS classification of HCC is correlating with the degree of differentiation and Ki-67 index.
