Prostacyclin synthase C1117A polymorphism is not associated with variant angina.
- Author:
In Whan SEONG
1
;
Dae Seung LIM
;
Jeong Hee KIM
;
Jae Hwan LEE
;
Si Wan CHOI
;
Jin Ok JEONG
Author Information
1. Department of Internal Medicine, Chungnam National University, College of Medicine, Daejeon, Korea. jojeong@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Variant angina;
Prostacyclin polymorphism
- MeSH:
Codon;
Coronary Angiography;
Coronary Vessels;
Endothelium-Dependent Relaxing Factors;
Epoprostenol*;
Ergonovine;
Exons;
Genotype;
Humans;
Polymorphism, Single Nucleotide;
Spasm
- From:Korean Journal of Medicine
2004;66(4):383-388
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Coronary artery spasm plays an important role in the pathogenesis of variant angina (VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. METHODS: We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenous ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C1117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. RESULTS: There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. CONCLUSION: The C1117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.
